What is Adagrasib used for?

non-small cell lung cancer with a KRAS G12C change; colorectal cancer with a KRAS G12C change, together with the antibody cetuximab.

What are the common side effects of Adagrasib?

Nausea and vomiting. Diarrhea. Feeling tired. Less appetite. Swelling in the legs or feet. Muscle or bone pain. Changes in liver or kidney blood tests.

When should I call my care team while taking Adagrasib?

Vomiting or diarrhea that will not stop, or you cannot keep fluids down; Yellow skin or eyes, dark urine, or pain on the right side of your belly; A fast, slow, or pounding heartbeat, or feeling like you might faint; New or worse cough, shortness of breath, or chest pain; Peeing much less than normal.

Adagrasib

Say it: ad-uh-GRA-sib · Brand names: Krazati

Adagrasib is a targeted pill that blocks a growth signal in cancers with a KRAS G12C gene change.

What it is

Some cancers have a change in a gene called KRAS, known as G12C. This change keeps a growth switch turned on. Adagrasib locks the switch in the off position.

Often used for

non-small cell lung cancer with a KRAS G12C change
colorectal cancer with a KRAS G12C change, together with the antibody cetuximab

How you get it

It is a pill you take by mouth twice a day, with or without food. People usually take it for as long as it works. Your schedule may be different.

Common side effects and what helps

Nausea and vomiting. Eat small, bland meals and ask about nausea medicine.
Diarrhea. Drink plenty of fluids and ask your team which diarrhea medicine to keep at home.
Feeling tired. Rest when you need to and take short walks when you can.
Less appetite. Try small meals and snacks through the day.
Swelling in the legs or feet. Raise your legs when sitting.
Muscle or bone pain. Ask your team what pain medicine is safe for you.
Changes in liver or kidney blood tests. Your team will check these.

Call your care team right away if you have

Vomiting or diarrhea that will not stop, or you cannot keep fluids down
Yellow skin or eyes, dark urine, or pain on the right side of your belly
A fast, slow, or pounding heartbeat, or feeling like you might faint
New or worse cough, shortness of breath, or chest pain
Peeing much less than normal

Before you start, tell your team

If you have heart rhythm problems or take medicines that affect heart rhythm
If you have liver or kidney problems
If you are pregnant, may become pregnant, or are breastfeeding
All the medicines, vitamins, and herbal products you take, since some can change how this medicine works

Good to know

Stomach and bowel side effects are common. Your team may give you medicine to prevent them.
It can change your heart rhythm. You may have ECGs (heart tracings) and blood tests for salts like potassium and magnesium.
You will have regular liver blood tests.
Rarely, it causes serious lung swelling.

At home

Take it at about the same times each day.
Swallow the pills whole with water. Do not crush, chew, or split them unless your team says it is OK.
If you miss a dose or throw up after a dose, ask your team what to do. Do not take an extra dose on your own.
Store the pills at room temperature in their original container, away from children and pets.
Wash your hands after touching the pills. Ask your team if others in your home should take special care.

Questions to ask

How long will I take this medicine?
What tests will I need, and how often?
Are any of my other medicines, foods, or supplements a problem with this medicine?
What should I do if I miss a dose?
Which side effects should I call you about right away, and which can wait?

Side effect guides

Sources

Quick answers

What is Adagrasib?: Adagrasib is a targeted pill that blocks a growth signal in cancers with a KRAS G12C gene change. Brand names: Krazati.
What is Adagrasib used for?: non-small cell lung cancer with a KRAS G12C change; colorectal cancer with a KRAS G12C change, together with the antibody cetuximab.
How is Adagrasib given?: It is a pill you take by mouth twice a day, with or without food. People usually take it for as long as it works. Your schedule may be different.
What are the common side effects of Adagrasib?: Nausea and vomiting. Diarrhea. Feeling tired. Less appetite. Swelling in the legs or feet. Muscle or bone pain. Changes in liver or kidney blood tests.
When should I call my care team while taking Adagrasib?: Vomiting or diarrhea that will not stop, or you cannot keep fluids down; Yellow skin or eyes, dark urine, or pain on the right side of your belly; A fast, slow, or pounding heartbeat, or feeling like you might faint; New or worse cough, shortness of breath, or chest pain; Peeing much less than normal.

Last updated: 2026-10-27. Medically reviewed by Veli Bakalov, MD, medical oncologist (October 2026). General education from Step by Step, the patient portal of HemeOncBuddy.